TAK-243 preferentially certain to UBA1 about the relevant E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, enhanced markers of proteotoxic worry and DNA harm strain. In vivo, TAK-243 lowered leukemic stress and qualified leukemic stem cells with out https://chelwoode196vaf9.national-wiki.com/user