Pentobarbital will decrease the level or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not recommended; stark cytochrome P450 enzyme inducers decrease systemic exposure to roflumilast and may reduce the therapeutic effectiveness pentobarbital will decrease the level or effect of estrogens esterified by affecting hepat... https://franciscossqnm.pointblog.net/lite-kända-fakta-om-vilka-är-alternativen-till-pentobarbital-71803271