Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts in the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions, which ... https://edenc322vma0.eedblog.com/profile