At an oral dose of 2000 mg/kg/day in rats, maternal toxicity and deaths had been seen with an elevated incidence of early fetal resorption; spontaneous abortions happened in cynomolgus monkeys for the maternally toxic oral dose of 2000 mg/kg/working day; there aren't any sufficient and well-controlled trials in Expecting Females; https://christopherv009hrc2.ttblogs.com/profile