Reduced Representation Bisulfite Sequencing (RRBS) is an important tool for studying DNA methylation. It is enriched for CpG-rich regions by restriction endonuclease cleavage, followed by bisulfite treatment, which converts unmethylated cytosine to uracil, while methylated cytosine remains unchanged. This technique can accurately locate methylation sites at single base resolution whil... https://www.cd-genomics.com/epigenetics/resource-rrbs-data-analysis-software.html