You will find there's release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lower afferent discomfort transmission and make analgesia. Hence, medication like clonidine that goal alpha-two receptors can affect the transmission of pain. Relates to clonidine: oral pill, oral https://www.proleviate.com/post/the-new-pain-killer-conolidine